epigenetically_modified_region
SO:0001720
Definition: A biological DNA region implicated in epigenomic changes caused by mechanisms other than changes in the underlying DNA sequence. This includes, nucleosomal histone post-translational modifications, nucleosome depletion to render DNA accessible and post-replicational base modifications such as cytosine modification.
Comments and references
Moved from is_a biological_region (SO:0001411) to is_a regulatory_region (SO:0005836) on 11 Feb 2021. GREEKC members pointed out that this would be a more appropriate location. See GitHub Issue #530. 11 Feb 2021 updated definition along with addition of epigenomically_modified_region (SO:0002332). Epigenetically modified region is now not inherited while epigenomically modified region is not annotated as inherited. See GitHub Issue #532 and issue #534.
Definition references: SO:ke, http://en.wikipedia.org/wiki/Epigenetics
Synonyms
| Scope | Value |
|---|---|
| related | epigenetically modified region |
Identifiers and subsets
Accession: SO:0001720
Persistent URL: http://purl.obolibrary.org/obo/SO_0001720
Alternate IDs: None
Subsets: SOFA
Cross references: None
History summary
Term history is reconstructed from the Git-era ontology files by comparing ontology classes across revisions. Earlier SVN-era changes will be added at a future date.
First seen in Git-era editable history: 2016-12-05 in commit 92e3cae
Most recent Git-era change: 2021-02-16 in commit 7777cdf
Number of changes: 5
Ontology neighborhood diagram
Relationships
Parents
Children
http://purl.obolibrary.org/obo/so#has_quality (outgoing)
http://purl.obolibrary.org/obo/so#overlaps (incoming)
Change history
This timeline summarizes changes identified in SO’s GitHub commit history, including updates to labels, definitions, parent terms, synonyms, subsets, and obsoletion status. It is a best-effort reconstruction and may not include every change to a term. Since only history from GitHub is included at the moment, any term added before the migration from SVN to Git will show as being created in 2016. This will be addressed once SVN history is incorporated.
| Date | Change | Summary | Evidence |
|---|---|---|---|
| 2021-02-16 | definition changed | Definition updated Before: A region of DNA that is modified in such a way that chromatin folding and transcription may be modified with no changes in the underlying DNA sequence. Examples include changes in DNA methylation status and regions bound by modified histones. After: A biological DNA region implicated in epigenomic changes caused by mechanisms other than changes in the underlying DNA sequence. This includes, nucleosomal histone post-translational modifications, nucleosome depletion to render DNA accessible and post-replicational base modifications such as cytosine modification. | 7777cdf#534 |
| 2021-02-11 | definition changed | Definition updated Before: A biological region implicated in inherited changes caused by mechanisms other than changes in the underlying DNA sequence. After: A region of DNA that is modified in such a way that chromatin folding and transcription may be modified with no changes in the underlying DNA sequence. Examples include changes in DNA methylation status and regions bound by modified histones. | d653e88#532 |
| 2021-02-11 | parent removed | Parent removed: SO:0001411 | db3bb81#530 |
| 2021-02-11 | parent added | Parent added: SO:0005836 | db3bb81#530 |
| 2016-12-05 | created | Term introduced into the editable ontology history Initial label: epigenetically_modified_region Initial definition captured. Initial parent: SO:0001411 | 92e3cae |