Sequence Ontology

A shared vocabulary for biological sequence features and annotations

Home / Current release / SO:0000392

U2_snRNA

SO:0000392

Definition: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

Comments and references

Definition references: http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00004

Synonyms

ScopeValue
exactU2 small nuclear RNA
exactU2 snRNA
exactsmall nuclear RNA U2
exactsnRNA U2

Identifiers and subsets

Accession: SO:0000392

Persistent URL: http://purl.obolibrary.org/obo/SO_0000392

Alternate IDs: None

Subsets: SOFA

Cross references: http://en.wikipedia.org/wiki/U2_snRNA

History summary

Term history is reconstructed from the Git-era ontology files by comparing ontology classes across revisions. Earlier SVN-era changes will be added at a future date.

First seen in Git-era editable history: 2016-12-05 in commit 92e3cae

Most recent Git-era change: 2016-12-05 in commit 92e3cae

Number of changes: 1

Ontology neighborhood diagram

Ontology neighborhood for SO:0000392 Ontology neighborhood graph for SO:0000392 U2_snRNA. Parent, child, and related nodes can be activated to open their term pages. SO:0000274 snRNA SO:0000274 snRNA SO:0000392 U2_snRNA SO:0000392 U2_snRNA
The local DAG shows nearby parent, child, and related terms. Each node links to its own term page.

Relationships

Parents

Children

None recorded in the current release neighborhood.

Change history

This timeline summarizes changes identified in SO’s GitHub commit history, including updates to labels, definitions, parent terms, synonyms, subsets, and obsoletion status. It is a best-effort reconstruction and may not include every change to a term. Since only history from GitHub is included at the moment, any term added before the migration from SVN to Git will show as being created in 2016. This will be addressed once SVN history is incorporated.

DateChangeSummaryEvidence
2016-12-05createdTerm introduced into the editable ontology history
Initial label: U2_snRNA
Initial definition captured.
Initial parent: SO:0000274
92e3cae