Changes to the structure of the SO regarding miRNA.
Revisions to SO relating to microRNA has been undertaken to include a more recent view of functional miRNA products with less emphasis on genomic origin. miRNA features were previously defined in terms of the canonical biogenesis pathway but in light of recent studies, precursor-miR sequences can be encoded by a more diverse set of non coding RNA transcripts and intronic sequence. In addition to miRNA genes, miRtrons, and a subset of noncoding RNA primary transcripts (snoRNA, lncRNA, tRNA, shRNA, vaultRNA and Y-RNA) all may contain pre-miR features. Also the pre-miR is now composed of miR, moR and LoR sequences to reflect the functional RNA products derived from this sequence. This work is in collaboration with Thomas Desvignes at the University of Oregon, Eugene.