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RNase_P_RNA    (CURRENT_RELEASE)

SO Accession: SO:0000386 (SOWiki)
Definition: The RNA component of Ribonuclease P (RNase P), a ubiquitous endoribonuclease, found in archaea, bacteria and eukarya as well as chloroplasts and mitochondria. Its best characterized activity is the generation of mature 5 prime ends of tRNAs by cleaving the 5 prime leader elements of precursor-tRNAs. Cellular RNase Ps are ribonucleoproteins. RNA from bacterial RNase Ps retains its catalytic activity in the absence of the protein subunit, i.e. it is a ribozyme. Isolated eukaryotic and archaeal RNase P RNA has not been shown to retain its catalytic function, but is still essential for the catalytic activity of the holoenzyme. Although the archaeal and eukaryotic holoenzymes have a much greater protein content than the bacterial ones, the RNA cores from all the three lineages are homologous. Helices corresponding to P1, P2, P3, P4, and P10/11 are common to all cellular RNase P RNAs. Yet, there is considerable sequence variation, particularly among the eukaryotic RNAs.
Synonyms: INSDC_qualifier:RNase_P_RNA, RNase P RNA, INSDC_feature:ncRNA
DB Xrefs: URL: http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00010  

Parent: ncRNA (SO:0000655)
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Graph image for SO:0000386