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mini_gene    (CURRENT_SVN)

SO Accession: SO:0000815 (SOWiki)
Definition: By definition, minigenes are short open-reading frames (ORF), usually encoding approximately 9 to 20 amino acids, which are expressed in vivo (as distinct from being synthesized as peptide or protein ex vivo and subsequently injected). The in vivo synthesis confers a distinct advantage: the expressed sequences can enter both antigen presentation pathways, MHC I (inducing CD8+ T- cells, which are usually cytotoxic T-lymphocytes (CTL)) and MHC II (inducing CD4+ T-cells, usually 'T-helpers' (Th)); and can encounter B-cells, inducing antibody responses. Three main vector approaches have been used to deliver minigenes: viral vectors, bacterial vectors and plasmid DNA.
Synonyms: mini gene
DB Xrefs: PMID: 15992143  

Parent: ORF (SO:0000236)

Child: rescue_mini_gene (SO:0000795)
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Graph image for SO:0000815