siRNA
SO:0000646
Definition: A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. siRNAs trigger the cleavage of their target molecules.
Comments and references
Definition references: PMID:12592000
Synonyms
| Scope | Value |
|---|---|
| exact | INSDC_qualifier:siRNA |
| exact | small interfering RNA |
| broad | INSDC_feature:ncRNA |
Identifiers and subsets
Accession: SO:0000646
Persistent URL: http://purl.obolibrary.org/obo/SO_0000646
Alternate IDs: None
Subsets: SOFA
Cross references: http://en.wikipedia.org/wiki/SiRNA
History summary
Term history is reconstructed from the Git-era ontology files by comparing ontology classes across revisions. Earlier SVN-era changes will be added at a future date.
First seen in Git-era editable history: 2016-12-05 in commit 92e3cae
Most recent Git-era change: 2021-07-01 in commit cc6a29b
Number of changes: 6
Ontology neighborhood diagram
Relationships
Parents
Children
None recorded in the current release neighborhood.
Change history
This timeline summarizes changes identified in SO’s GitHub commit history, including updates to labels, definitions, parent terms, synonyms, subsets, and obsoletion status. It is a best-effort reconstruction and may not include every change to a term. Since only history from GitHub is included at the moment, any term added before the migration from SVN to Git will show as being created in 2016. This will be addressed once SVN history is incorporated.
| Date | Change | Summary | Evidence |
|---|---|---|---|
| 2021-07-01 | definition changed | Definition updated Before: A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules. After: A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. siRNAs trigger the cleavage of their target molecules. | cc6a29b |
| 2018-01-26 | synonym added | Synonym added: INSDC_qualifier:siRNA Scope: exact | 5fe48bd |
| 2018-01-26 | synonym added | Synonym added: INSDC_feature:ncRNA Scope: broad | 5fe48bd |
| 2017-09-18 | parent removed | Parent removed: SO:0000655 | e0db300 |
| 2017-09-18 | parent added | Parent added: SO:0000370 | e0db300 |
| 2016-12-05 | created | Term introduced into the editable ontology history Initial label: siRNA Initial definition captured. Initial parent: SO:0000655 | 92e3cae |